CRISPR Immunity

Bacterial Adaptive Immunity: Spacer Acquisition and Interference

Naive
Immune
Phage
Defense
Generation: 0
Naive Bacteria: 0
Immune Bacteria: 0
Phages: 0
Interferences: 0
Acquisitions: 0

CRISPR Array (Most Common Spacers)

CRISPR-Cas System

Acquisition: When a naive cell survives infection, it captures a piece of phage DNA (protospacer) and stores it as a spacer in its CRISPR array.
Interference: If a matching phage attacks later, Cas proteins use the spacer as a guide to recognize and destroy the invading DNA.
Phages can escape through mutations that change the protospacer sequence.